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B5 · HealthAQA GCSE Biology · 8461 (Triple)

Communicable Diseases & Defences

Pathogens (bacteria, viruses, fungi, protists), transmission routes, physical and chemical barriers, white blood cells. Paper 1.

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CognitoCommunicable diseases and pathogens
CognitoThe immune system
Key facts & methods

Types of pathogen — fill in the table

PathogenKey features
Bacteria
Viruses
Fungi
Protists
Key diseases

Transmission routes — fill in the table

RouteExamples
Direct contact
Droplet infection
Sexual contact
Water/food
Vectors

Physical and chemical defences — fill in the table

DefenceHow it works
Skin
Nose hairs and mucus
Cilia
Stomach acid
Tears

White blood cells (immune response) — fill in the table

Cell / substanceRole
Phagocytes
Lymphocytes
Antibodies
Memory cells
Antitoxins
Exam questions — 5 questions · 11 marks · AQA 8461 style
⚡ Show all reasoning — the AI marks against the AQA mark scheme. Partial credit for correct biology even if wording differs.
1 markPathogen typeAQA 8461 style

Malaria is caused by which type of pathogen?

A Virus
B Bacteria
C Fungus
D Protist
1 markAntibioticsAQA 8461 style

Why are antibiotics ineffective against viral infections?

A Viruses are too small for antibiotics to work on
B Antibiotics work on bacterial cell processes (e.g. cell wall synthesis) which viruses do not have
C Antibiotics are always destroyed by the immune system
D Viruses are protected by the host cell
3 marksPhysical defencesAQA 8461 P1 style

Describe THREE ways the human body prevents pathogens from entering or surviving inside it, before the immune system responds. (3 marks)

Hint: Think about barriers that stop entry (skin, mucus/cilia) and defences that kill pathogens that do get in (stomach acid, lysozyme).
+30 XP
4 marksImmune responseAQA 8461 style

Explain how lymphocytes protect the body against a specific pathogen, and why a second infection with the same pathogen produces a faster response. (4 marks)

Hint: Cover: recognition → antibody production → action of antibodies → memory cells → faster secondary response.
+40 XP
1 markMemory cellsAQA 8461 style

Why do memory cells allow a faster immune response to a second infection?

A They produce antitoxins rather than antibodies
B They are already programmed to produce the specific antibody and are present in large numbers, ready to divide rapidly
C They destroy the pathogen by phagocytosis before antibodies are needed
D They prevent the pathogen from reproducing inside cells
Quick recall flashcards

Module complete! 🎉

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